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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-12 (as Methylcobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Relevant treatment insights highlighted
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Read More
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
Significant but indirect association
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
8
Effects of vitamin B12 treatment
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
Addresses B12 along with B6
We explored the effects of vitamin B12 treatment in two young male patients with pulmonary thromboembolism associated with protein C and protein S deficiencies. Both patients experienced a range of symptoms including chest pain, alongside lower limb pain and visual disturbances. Their diagnosis came after imaging tests revealed deep venous thrombosis and subsequent pulmonary embolism.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
Read More
Most Useful Reviews
9.5
Chest pain resolved
I had sciatica for over six months, resulting in chest pain from my buttocks to my thighs. After starting B12 alongside vitamin D, I noticed significant improvement. Within three days, the pain disappeared. While my feet remain numb, I hope this will also improve. The tablets dissolve easily on the tongue; I find them effective and would recommend them for neuralgia.
Read More
8.8
Pain relief observed
Outstanding effect on peripheral nerves. I initially took it to improve perception and language function, but noticed unexpected relief from chest pain in my lumbar spine. Due to sitting for long hours at work, I experienced discomfort, and medications carried side effects. Methyl cobalamin provided significant relief when taken multiple times daily. I now take 5000 mcg twice a day.
Read More
9.5
Pain vanished quickly
My fingers, except for my little finger, were numb, particularly my index and thumb causing chest pain. After researching, I discovered B12 could help, and I started taking it. Soon, the pain disappeared, and I regained normal use of my fingers. I was evidently B12 deficient, so I continued taking it and store it in the fridge.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
9.5
Pernicious anemia and thromboembolism
Hyperhomocysteinemia due to pernicious anemia leading to pulmonary thromboembolism in a heterozygous mutation carrier.
Limited isolation of vitamin B12
We explored a case involving a 46-year-old woman who experienced chest pain and hemoptysis, leading to the discovery of a pulmonary thromboembolism. Upon further evaluation, we found that her homocysteine levels were high and that she had low vitamin B12 and iron levels due to pernicious anemia.
Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.
Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.
In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Although she was diagnosed with multiple conditions, including pernicious anemia and iron-deficiency anemia, an interesting aspect of her treatment was the supplementation with vitamin B12 along with other necessary nutrients like pyridoxine, thiamine, folic acid, and iron. At the end of the therapy, not only did her vitamin B12 and folate levels return to normal, but also her homocysteine levels and red cell volume improved.
Ultimately, repeat imaging showed that the thrombus had completely resolved, suggesting a comprehensive approach to her treatment was effective. While vitamin B12 was part of her therapy, it was combined with several other treatments. Therefore, it is challenging to isolate its specific impact on her initial chest pain.
In summary, our findings point toward vitamin B12’s potential role in addressing underlying causes of hyperhomocysteinemia, but its direct effect on chest pain remains less clear-cut given the multifaceted treatment she received.
Read More
9.5
Vitamin B12 not isolated in study
Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.
Significant but indirect association
We examined a group of 42 women suffering from chest pain but having normal coronary arteries, known as cardiac syndrome X. Our aim was to understand the link between a specific gene mutation (C677T) and abnormal homocysteine metabolism, a condition that may influence endothelial cell dysfunction, which has been tied to chest pain.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
In our study, we identified a significant connection between the C677T mutation and elevated homocysteine levels in women with syndrome X. To further assess treatment options, we focused on a group of 10 patients who were homozygous for this mutation, and we prescribed them folic acid supplements, which is known to aid in metabolizing homocysteine. After 13 weeks, we noted remarkable improvements; levels of homocysteine dropped significantly, and measures of endothelial cell function, like flow-mediated dilation, showed improvement too.
Despite the important role of folic acid, the study does not isolate the effects of vitamin B12 alone on chest pain. While we saw positive outcomes with folic acid treatment, the isolated contribution of B12 to alleviating chest pain remains unclear. Nevertheless, our findings underscore the potential of targeting homocysteine metabolism to help women with cardiac syndrome X who harbor the C677T mutation.
Read More
8
Vitamin B12 improves chest pain
Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency.
Relevant treatment insights highlighted
We observed an intriguing case involving a patient suffering from chest pain alongside severe anemia and vitamin B12 deficiency. The patient, a 44-year-old Hispanic woman, presented with escalating non-radiating chest pain, fatigue, and shortness of breath over three weeks. Her lab results showed critical pancytopenia and macrocytosis, raising concerns about a rare condition known as pseudo-thrombotic microangiopathy (TMA), which can occur due to vitamin B12 deficiency.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Initially diagnosed with pseudo-TMA, the patient was undergoing plasmapheresis and steroid treatment. However, once she received daily injections of 1000 micrograms of parenteral vitamin B, her condition began to improve significantly, leading to a resolution of her symptoms, including the chest pain.
This case highlights the importance of considering vitamin B12 deficiency in patients presenting with hemolytic anemia and chest pain. Often misdiagnosed as other conditions, patients may receive unnecessary treatments that delay the correct intervention. It’s vital to recognize the role of sufficient vitamin B12 in addressing specific symptoms like chest pain in such contexts.
Read More
8
Effects of vitamin B12 treatment
[Two cases of pulmonary thromboembolism associated with protein C and protein S deficiency and literature review].
Addresses B12 along with B6
We explored the effects of vitamin B12 treatment in two young male patients with pulmonary thromboembolism associated with protein C and protein S deficiencies. Both patients experienced a range of symptoms including chest pain, alongside lower limb pain and visual disturbances. Their diagnosis came after imaging tests revealed deep venous thrombosis and subsequent pulmonary embolism.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
In the course of treatment, we noticed that the patients exhibited poor responses to standard anticoagulant therapies. To tackle this, vitamin B6 and B12 were introduced as part of their regimen. Remarkably, upon adding vitamin B12, we observed significant improvement in the patients' symptoms, such as reduced chest pain.
These findings suggest that vitamin B12 may play a beneficial role in managing symptoms of chest pain linked to this type of thromboembolic event, particularly in patients with underlying deficiencies. It’s important we recognize congenital thrombophilia when dealing with such cases, especially in younger individuals with unexplained recurrent complications before the age of 40.
Read More
7
Vitamin B12's effect on angina
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.
Concerns on vitamin B12 benefits
We explored the case of a 53-year-old woman with stable angina, who also experienced three unexplained first-trimester miscarriages. Her health evaluations revealed moderate hyperhomocysteinemia attributed to a genetic mutation known as MTHFR C677T. This condition, along with factors like abdominal obesity and post-menopausal status, raised concerns about her cardiovascular and reproductive health.
The patient began a treatment regimen that included vitamins B6, B12, and folic acid, alongside standard angina therapy. Notably, two months into this treatment, her homocysteine levels decreased by 28.6%, and there was a reported improvement in her overall clinical condition. However, it’s important to note that while vitamin supplementation showed effectiveness in lowering homocysteine levels, current evidence doesn’t strongly support that this leads to a significant reduction in cardiovascular events.
As we consider the role of vitamin B12 in treating chest pain, we recognize the complex relationship between homocysteine levels and cardiovascular health. While the vitamin may contribute positively to certain health outcomes, its isolated effect in preventing chest pain remains unclear and needs more research.
The patient began a treatment regimen that included vitamins B6, B12, and folic acid, alongside standard angina therapy. Notably, two months into this treatment, her homocysteine levels decreased by 28.6%, and there was a reported improvement in her overall clinical condition. However, it’s important to note that while vitamin supplementation showed effectiveness in lowering homocysteine levels, current evidence doesn’t strongly support that this leads to a significant reduction in cardiovascular events.
As we consider the role of vitamin B12 in treating chest pain, we recognize the complex relationship between homocysteine levels and cardiovascular health. While the vitamin may contribute positively to certain health outcomes, its isolated effect in preventing chest pain remains unclear and needs more research.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.7
9.5
Pain vanished quickly
My fingers, except for my little finger, were numb, particularly my index and thumb causing chest pain. After researching, I discovered B12 could help, and I started taking it. Soon, the pain disappeared, and I regained normal use of my fingers. I was evidently B12 deficient, so I continued taking it and store it in the fridge.
Read More
9.5
Chest pain resolved
I had sciatica for over six months, resulting in chest pain from my buttocks to my thighs. After starting B12 alongside vitamin D, I noticed significant improvement. Within three days, the pain disappeared. While my feet remain numb, I hope this will also improve. The tablets dissolve easily on the tongue; I find them effective and would recommend them for neuralgia.
Read More
8.8
Pain relief observed
Outstanding effect on peripheral nerves. I initially took it to improve perception and language function, but noticed unexpected relief from chest pain in my lumbar spine. Due to sitting for long hours at work, I experienced discomfort, and medications carried side effects. Methyl cobalamin provided significant relief when taken multiple times daily. I now take 5000 mcg twice a day.
Read More
8.8
Neuralgia improvement noted
This vitamin aids the recovery of damaged nerves. I learned that B12 is prescribed for neuralgia following herpes zoster, so I tried it for my family. It absorbed well sublingually and tasted pleasant. I used to suffer from chest pain due to postherpetic neuralgia, but I've found relief now. After finishing one bottle, I feel healed and will use it again if needed.
Read More
